The FA announced that England will face Wales on October 8 at a friendly Wembley Stadium.
The game will be played behind closed doors until both sides return the weekend afterwards to the action of the League of Nations.
It will be the first meeting of the home nations since Daniel Sturridge’s last-minute winner gave England a 2-1 victory during the group stages of Euro 2016.
The fixture will also be the first international to be played at Wembley since the outbreak of the coronavirus, with no supporters there.
England will take on the rivals of the Nations League Iceland and Denmark in September but both games are away from home, with Gareth Southgate keen to repeat the success of making the competition’s final for the second time.
Ryan Giggs’ Wales will make the short trip three days after the Wembley friendly to face the Republic of Ireland, while England will host Belgium on the same day.